Systems Biology & Computational Biophysics
My work combines sequential data, structural biology and various modeling appraoches to investigate protein properties and the systemic impact of their alterations on biological function. One of my central pillars is the mapping how molecular structures, their dynamics and cell signaling drive disease and therapy.
Cell Signaling & Kinetic Modeling
I construct and simulate kinetics models describing cytokine signaling pathways (e.g., Interferon-γ immune response). By analyzing immune response dynamics, I help define the mechanisms of disease and the potential curative power of new molecular derivatives.
Molecular Dynamics & Biophysics
I perform extensive MD simulations (e.g., RAF Kinases, Ribonucleases) to reveal regulatory mechanisms and structure-function relationships. My work explores how protein dynamics influence experimental outcomes and binding affinities.
Interactomics & Meta-Analysis
I utilize genome-wide meta-analyses to investigate interacting partners of small GTPases (Ras/Rho), providing insights into cancer development and Rasopathies. I’ve developed concepts for common interacting interfaces within phylogenetic families to predict multidomain protein function.